Palindromic Rheumatism (PR)

How to pronounce it:

Palindromic - pAL-in-droh-mic

Rheumatism - roo-muh-TIZ-em


AiArthritis defines palindromic rheumatism as:


Palindromic rheumatism (pal-in-drom-ic roo-ma-tiz-em) is a form of inflammatory arthritis. It causes attacks or flare-ups of joint pain and inflammation that come and go. The joints look and feel normal between attacks, and the attacks don’t cause any lasting damage to the joints. Palindromic rheumatism affects both men and women equally and typically affects people between the ages of 20 and 50.


Symptoms

Symptoms of AiArthritis Diseases Regardless of Diagnosis

Common in All AiArthritis Diseases



  • Periods of worsening symptoms are called flares. A flare can last for hours, days, weeks, or months.
  • Condition improves with activity and exercise and worsens with rest.
  • When inflammation is left uncontrolled due to lack of proper treatment, comorbidities can develop. 70% of patients with chronic, lifelong disease will develop comorbidities, including dual or triple diagnoses.
  • Autoimmune diseases run in families. If anyone in your immediate family (parents, siblings) or extended family (aunts, uncles, grandparents) have been diagnosed with ANY autoimmune disease, there is the possibility of genetic predisposition.

 “Auto” Symptoms






  • Severe fatigue or exhaustion that may not be helped by caffeine/stimulants and can happen even after a long period of rest.
  • “Brain fog” - or periods of time where thinking gets clouded and it becomes difficult to concentrate.
  • Flu-like symptoms, without having the flu- nausea, muscle weakness, and general malaise.
  • Fever, typically low grade in autoimmune and higher grade in autoinflammatory (% strongly varies per disease).


Reference: Early Symptoms of AiArthritis Study, AiArthritis, 2019.


View Early Symptoms Study

Inflammatory Arthritis Symptoms


  • Severe stiffness in one or more joints, especially in the morning or after sitting for long periods of time. 
  • Episodes of joint pain that may last for hours, days, or even weeks, that can appear and disappear suddenly. Often described as “jumping pain” into different locations.


Typically the joint pain will coincide with one or more “Auto” symptoms and start and stop suddenly - for no apparent reason (which is called a "flare").  Some people will experience all of the above symptoms, others only a few.  If you have any of the arthritis features, and at least one of the “Auto” features, please consult your physician about a referral to a rheumatologist.


Symptoms Often Associated with Palindromic Rheumatism:

  • Sudden, multiple, recurring attacks (last a few hours to a few days), return back to normal after
  • Tendon pain and stiffness
  • Joint commonly affected: fingers, wrists, and knees
  • Limited range of motion during flare


What fellow patients want you to know

Do you have Palindromic Rheumatism? Let us know what YOU would want those with Palindromic Rheumatism or those who are not yet diagnosed to know!

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More About Palindromic Rheumatism

Diagnosing Palindromic Rheumatism

There’s no single definitive test that can confirm a palindromic rheumatism diagnosis, so rheumatologists look at a combination of physical exam, blood tests (ESR, CRP, antibody tests), and imaging (x-ray), along with a family history of autoimmune or autoinflammatory disease. It is important to try to get tests and imaging done during an attack or flare since the symptoms are intermittent. If unable to get to a doctor during the attack, documenting symptoms with pictures and logs is essential.

Interesting Facts about this Disease

  • The cause of palindromic rheumatism is unknown, although a possible allergic origin has been suggested.
  • About 33-50% of the people who have palindromic rheumatism eventually develop rheumatoid arthritis (RA)

Other Resources

In an effort to ensure this page has the most accurate and up-to-date information, this page is currently awaiting medical review. Some information is subject to change.


Page Last Updated: 9/1/2023

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