Schnitzler syndrome is a rare autoinflammatory disease. It is characterized with patients having non-pruritic urticaria (or non-itchy hives) and blood abnormalities including elevated levels of specific proteins (monoclonal IgM gammopathy).
Symptoms of AiArthritis Diseases Regardless of Diagnosis
“Auto” Symptoms
Reference: Early Symptoms of AiArthritis Study, AiArthritis, 2019.
Typically the joint pain will coincide with one or more “Auto” symptoms and start and stop suddenly - for no apparent reason (which is called a "flare"). Some people will experience all of the above symptoms, others only a few. If you have any of the arthritis features, and at least one of the “Auto” features, please consult your physician about a referral to a rheumatologist.
Symptoms Often Associated with Schnitzler Syndrome:
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There’s no single definitive test that can confirm a Schnitzler syndrome diagnosis, so rheumatologists look at a combination of physical exam, blood tests, and imaging, along with a family history of autoimmune or autoinflammatory disease.
For Schnitzler syndrome diagnosis, patient must have both of the major criteria:
Plus at least 2 of the following minor criteria:
Someone can also get diagnosed if they have monoclonal IgM gammopathy and 3 of the secondary symptoms.
In an effort to ensure this page has the most accurate and up-to-date information, this page is currently awaiting medical review. Some information is subject to change.
Page Last Updated: 9/1/2023
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